Symptoms of infection include fever, headache, abdominal pain, vomiting, and muscle pain. A rash may sometimes develop, but occurs several days after infection and may never develop in some people. Symptoms typically occur 2-14 days after the bite of an infected tick. Treatment of Rocky Mountain spotted fever is most effective if treatment is started within 5 days of infection. If treatment does not occur within 8 days, the disease can turn fatal. Diagnosis must be made by a physician and is based on clinical signs and symptoms, medical history, and specialized laboratory tests. Severe cases of Rocky Mountain spotted fever may result in hospitalization and long-term effects such bleeding and clotting issues, loss of circulation to extremities. Rocky Mountain spotted fever is easily treated if diagnosed early. There are currently no preventative vaccines or medications.