The cause of STARI is unknown. The most significant symptom is a rash similar to the rash of Lyme disease. Other symptoms that may accompany the rash include fatigue, fever, headache, muscle and joint pains. Treatment involves antibiotics, but it is unknown if antibiotics spread the recovery of infected individuals. STARI rashes typically within 7 days. Diagnosis is based on symptoms, geographic location, and history or possibility of a tick bite. Diagnosis and treatment of STARI must be done by a healthcare professional. There are no known diagnostic tests to confirm infection and while infections are treated with antibiotics, it is unknown if this treatment is necessary or beneficial to patients.