The widespread use of hydraulic fracturing (HF) has enabled a dramatic expansion of unconventional natural gas extraction in the U.S. While life cycle greenhouse gas (LC-GHG) emissions associated with HF have gained attention in recent years, little focus has been devoted to upstream LC-GHG impacts of HF natural gas (Clark, Burnham, Harto, & Horner, 2013; Verrastro, 2012). Focusing on 1,921 wells in Pennsylvania from 2012 to 2013, we used the Economic Input-Output Life Cycle Assessment model to assess LC-GHG emissions associated with production and transportation of chemicals and sand mining. Ton-miles from the transportation of sand and water were assessed with life cycle transportation emissions factors to generate LC-GHG emissions. LC-GHG emissions from upstream inputs assessed in this study equaled 1,374 tons of CO2e per well, but account for only 0.63% of the total LC-GHG emissions of HF natural gas. LC-GHG emissions from sand, water, and chemicals are quite small when compared with gas combustion, methane leakage, venting, and flaring from the other phases of the HF process.